#4331 UPREGULATION OF ADIPOSE TISSUE FATTY ACID-BINDING PROTEIN 4 IN PATIENTS WITH CHRONIC KIDNEY DISEASE: IMPLICATIONS FOR DYSFUNCTIONAL VASCULAR CELLS

Abstract Background and Aims FABP4, a fatty acid-binding protein, is predominantly expressed in adipose tissue (AT) has been shown to be elevated patients with chronic kidney disease (CKD). Although levels of FABP4 have linked cardiovascular end-stage renal (ESRD) patients, the cause this increase unclear. The aim study was evaluate expression AT under uremic conditions its impact on function macrophages vascular smooth muscle cells (VSMC). Method We measured blood urine CKD patients. analyzed using omental obtained from healthy donors ESRD who received peritoneal catheter insertion. effect VSMC also assessed. Results were inversely correlated their estimated glomerular filtration rate (eGFR). An detected before urine. found higher mature adipocytes visceral compared stromal fraction (SVF). Adipocytes treated p-cresol isolated showed individuals. Single-cell RNA sequencing SVF increased progenitor In THP-1 cells, induced more foam inflammatory mediators presence palmitic acid. or mice by an adenine diet pro-calcific phenotype, as indicated calcium content bone-related gene expression, which further enhanced FABP4. Conclusion are not solely result decreased clearance but due production AT. These circulating may associated dysfunction cells.